Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages
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چکیده
منابع مشابه
Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages
The ubiquitin proteasome system (UPS) directs programmed destruction of key cellular regulators via posttranslational modification of its targets with polyubiquitin chains. These commonly contain Lys-48 (K48)-directed ubiquitin linkages, but chains containing atypical Lys-11 (K11) linkages also target substrates to the proteasome--for example, to regulate cell cycle progression. The ubiquitin l...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2015
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e15-02-0102